Centre for Pulmonology

According to a report by the World Health Organization, deaths due to pulmonary diseases in India have been on the rise, accounting for 11 percent of the total deaths. India bears 32 percent of the global burden of respiratory diseases. COPD and Asthma were responsible for 75.6% and 20.0% of chronic respiratory diseases.

Asthma causes swelling of the airways. This results in the narrowing of airways that carry air from the nose and mouths to the lungs. Symptoms include trouble in breathing, wheezing, coughing, and tightness in the chest.

IL-4, IL-5, IL-9, and IL-13 show the potential pathogenic role and are secretory products of stimulated macrophages and other cells. Increased levels of these cytokines result in inflammation in the respiratory tract including trachea, bronchi, bronchioles, alveoli, pleural cavity, and muscle respiration.

Our intervention is through RNAi which is the process of sequence-specific, transcriptional gene silencing through RNA. It is a method of controlling gene expression and has the potential for the development of drugs for pulmonary lung disease.