Understanding BIOFILM

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A discussion on our drug development related to biofilm-associated diseases.

I have always been curious about scientific innovations. This curiosity pushed me to pursue biotechnology as a career option. Exploring new dimensions and learning new things is what I always looked for in my life. And today being a part of VV Biotech I am excited about the discovery of a drug that contains RNA. By using this drug, the biofilm layers of bacteria responsible for causing certain diseases can be degraded.

What is a biofilm ?

A biofilm is made of different types of microorganisms in which cells adhere to one another and are regularly added to a surface. These adherent cells become embedded with a slimy extracellular matrix made out of extracellular polymeric substances (EPSs). The extracellular polysaccharides are further made up of lipid, RNA, DNA polysaccharides, etc. Since these have a three-dimensional structure and represent a community-style life for microorganisms, they have been figuratively described as "cities for microbes".

In our findings, we came across various cytokines and chemokines responsible for the biofilm-associated diseases. This list includes IL-1α, IL-1β, IL-6, IL-12, TNF-α, IL-4, IL-10, CCL-2, IL-8, and IL-2.

There are also various types of genes associated with biofilms such as TLR6, TNNI3, HRH2, TLR2, NFKB, ATP4A, APOE, LVRN, etc.

Biofilm Associated Diseases

Biofilms are responsible for certain diseases that create problems in our lives. Some of the diseases caused by biofilms are Septicemia, Endocarditis, Meningitis, Endophthalmitis, and chronic obstructive pulmonary disorder.

Biofilms represent a difficult issue for general wellbeing due to the increased obstruction of biofilm-related creatures to antimicrobial agents and the potential for these life forms to cause diseases in patients with inhabiting clinical device. Bacteria made by biofilm are difficult to remove because these bacteria make a thick protective layer and cover this layer like an umbrella to avoid the effect of any antibiotic.

The Role of our Drug

Biofilms bring a lot of disadvantages to human lives and are even capable of invading our cells. Since the protective shells made by biofilms are the real cause of keeping out potential treatments, we have focused on the degradation of these biofilms with the help of RNA. These RNAs are also capable of treating various biofilm-associated diseases.

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